Objective:This study aimed to compare the efficacy and safety of ciprofloxacin, a fluoroquinolone, against ciprofloxacin, a quinolone, in patients with moderate to severe bacterial exacerbations of chronic obstructive pulmonary disease (COPD) in a noninferiority study. Methods: A prospective, multicenter, randomized, double-blind, placebo-controlled study was conducted in the Department of Pulmonology, The Western Hospital, New Delhi, India. Patients were randomly assigned into two groups, a ciprofloxacin group (n=6) and a ciprofloxacin group plus a placebo group (n=6). Both groups were given 100 mg/day of ciprofloxacin. Patients were followed up for an additional 14 days. Results: The ciprofloxacin group showed a significantly better improvement in lung function than the ciprofloxacin group plus placebo group in the composite score of Global Assessment Questionnaire (GAQ) (2.1 ± 0.6 vs 2.0 ± 0.4, p<0.001) (see Table ). The ciprofloxacin group showed a significantly better improvement in the total and composite score of the WHO functional class questionnaire (0.7 ± 0.4 vs 1.1 ± 0.3, p<0.001) (see Table ). The placebo group showed a significantly better improvement in the total and composite scores of the WHO functional class questionnaire (0.7 ± 0.4 vs 0.3 ± 0.1, p<0.001) (see Table ). Conclusions: Ciprofloxacin demonstrated superior efficacy in improving lung function and the total and composite scores of the WHO functional class questionnaire. In patients with moderate to severe COPD, ciprofloxacin may be an appropriate alternative for the treatment of the underlying cause.
Keywords: ciprofloxacin, fluoroquinolone, lung function, functional classBackground: Fluoroquinolones, particularly ciprofloxacin, have been used to treat various infections caused by susceptible bacteria. These drugs are frequently prescribed due to their proven efficacy and safety profile. Despite their effectiveness, these drugs have become an increasing number of treatment choices in the United States and Europe, where the cost of treatment and the associated healthcare expenditures are substantial. This study aimed to compare the efficacy and safety of ciprofloxacin and ciprofloxacin plus a placebo for the treatment of moderate to severe bacterial exacerbations of chronic obstructive pulmonary disease (COPD). Methods: This randomized, double-blind, double-dummy, parallel-group study was conducted at the Department of Pulmonology, The Western Hospital, New Delhi, India. Patients with moderate to severe COPD who were treated with either ciprofloxacin or ciprofloxacin plus a placebo were randomized to receive either ciprofloxacin (n=5) or ciprofloxacin plus a placebo (n=6) in a 2:1 ratio. The study was conducted after a single dose of ciprofloxacin or ciprofloxacin plus a placebo for the treatment of moderate to severe exacerbations of COPD. Patients were followed up for 24 weeks, at which time the patients were asked to report their symptoms and their daily symptoms and were assessed at the same time using the WHO Functional Class (GAQ) questionnaire. Results: The ciprofloxacin group showed a significantly better improvement in total and composite score of the GAQ (0.6 ± 0.5 vs 1.1 ± 0.6, p<0.001) (see Table ). The ciprofloxacin group showed a significantly better improvement in the composite score of the WHO functional class questionnaire (0.7 ± 0.4 vs 0.3 ± 0.1, p<0.001) (see Table ).
Cipro (Ciprofloxacin) can be purchased by calling +1-888-704-0408 and talking with a customer service representative, or by placing an online order at liferxpharmacy.com. Customer Support is also aided by using the chat feature. For additional information, visit the "How to Order" page on liferxpharmacy.com.
Cipro (Ciprofloxacin) is a medication that can only be purchased with a doctors prescription. While processing your order for the medication, it is necessary to get a valid prescription from your doctor The prescription can be scanned, emailed, or uploaded at liferxpharmacy.com or fax on +1-800-986-4751 Alternatively, if you like, we can even contact your doctor to obtain a valid prescription.
The maximum amount of Cipro (Ciprofloxacin) can be ordered at one time is a 90-day supply. The amount that can be ordered is dependent on the instructions and quantity mentioned on your medical prescription. Refilling alternate is always available for future needs.
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Cipro (Ciprofloxacin) is available in both generic and brand form. Generic medicines contain the same active components as brand-name pharmaceuticals have. They ensure and meet the same quality, strength, and purity standards in comparison to any other brand.
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LifeRx pharmacy makes it simple to refill your medication. By going to your accounts reorder section, you can easily place a refill option available online. You may examine your prior orders and choose which prescriptions order needs to be refilled. To order a refill, you can also call us and chat with one of our customer service representatives. Our live chat is also one of the convenient ways to reach out to us while placing a refill order.
We do not automatically refill prescriptions as it might be the case where you may no longer be taking the same medicines or your doctor may have revised your dose, among other things. However, we do offer a helpful refill reminder service. Based on your prescription history, we may call or email you to let you know when the ideal time is to place a refill order.
casts.�| Days | Outgoing Pharmacy | ReorderCipro (Ciprofloxacin) is a powerful antibiotic medication used to treat a wide variety of bacterial infections. It belongs to the class of drugs called quinolone antibiotics. The main action of Cipro is to combat the harmful bacteria that cause infections. By targeting the bacteria's DNA, this medicine function cure the infection.
Cipro (Ciprofloxacin) comes in various strengths and is available in various dosage strengths depending on the infection you are treating. The recommended starting dose is 1 gram taken twice a day which may be increased to 2 or 3 milligrams on medical advice.
It varies might take a few days to have a full blown success as treatment but if you are still suffering from side effects, it’s important to inform your healthcare professional of your complete medical history before start taking Cipro (Ciprofloxacin).
The FDA has approved Ciprofloxacin Ophthalmic Ointment USP, 1% (Oral Suspension), for the treatment ofinfections caused by susceptible organisms. The ophthalmic suspension contains Ciprofloxacin as the active ingredient. It is indicated for the treatment ofin adults and in children under 6 years old. Ciprofloxacin ophthalmic Ointment USP contains anhydrous, light-flavoured ophthalmic particles which are less than 0.2 μm in size. They are not usually related to the drug and are not intended for topical use. In clinical trials, Ciprofloxacin ophthalmic Ointment USP was shown to be effective against infections of the conjunctival, corneal and cor Vision.
What is Ciprofloxacin Ophthalmic Ointment USP (Ciprofloxacin)?
Ciprofloxacin is an antibiotic. It is used in the treatment of bacterial infections. Ciprofloxacin ophthalmic Ointment USP is an ointment. It contains anhydrous, light-flavoured ophthalmic particles which are less than 0.2 μm in size. They are less than 0.2 μm in size and are not usually related to the drug and are not intended for topical use. In clinical trials, Ciprofloxacin ophthalmic Ointment USP was shown to be effective against infections of the conjunctival, cornea, cornea, vision on naked basis, of susceptible organisms. The ophthalmic particles are less than 0.2 μm in size, they are not usually related to the drug and are not intended for topical use. In clinical trials, Ciprofloxacin ophthalmic Ointment USP was shown to be effective against infections of the cornea, vision on naked basis, of susceptible organisms. In clinical trials, Ciprofloxacin ophthalmic Ointment USP is indicated for the treatment of bacterial infections. Ciprofloxacin Ophthalmic Ointment USP may be prescribed for the treatment of bacterial infections of the conjunctiva, cornea and vision on naked basis, of susceptible organisms, or for the treatment of corneal infections. It is indicated in infections caused by susceptible organisms in adults and in children under 6 years old. It is indicated in infections caused by susceptible organisms in children.
Who is this medicine for?
Ciprofloxacin Ophthalmic Ointment USP is indicated for the treatment ofinfections caused by susceptible organisms in adults and children under 6 years oldIt is indicated for the treatment of bacterial infections in adults and in children under 6 years old.Who should avoid or limit the use of this medicine?Ciprofloxacin Ophthalmic Ointment USP should be used with caution in the following conditions:severe ocular infections (such as cystitis, bacterial conjunctivitis, acute posterior chamber cellulitis, acute posterior membrane abscess, ophthalmopathy, ocular infections due to susceptible organisms or systemic infections)Do not use if the affected area has already been treated with Ciprofloxacin.
Cipro has been shown to cause some side effects. Talk to your health care provider if these mild reactions do not go away within a few days.
Common side effects reported from Cipro use include:
This is not a complete list of adverse reactions caused by Cipro.Call your doctor immediately if you experience the following:
Taking Cipro has been shown to impact your tendons (cords attaching bone to your muscles). It can increase your risk of developing tendonitis or a tendon rupture, especially if you’re over 60, taking steroid medications, or have a history of tendon problems.
Cipro can interact with other medications and substances, causing potentially serious side effects or allergic reactions. Tell your doctor if you are taking muscle relaxers such as tizanidine (Zanaflex), phosphodiesterase 5 (PDE5) inhibitors such as sildenafil, anticoagulants (blood thinners), antidepressants, antipsychotics, diuretics, insulin, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.
This is not a complete list of Cipro drug interactions, so discuss any medications you’re on, even if you don’t see them listed here. Cipro can cause low blood sugar in some patients. Be wary of low blood pressure symptoms such as blurred vision, fatigue, confusion, pale skin, and cold sweats. Watch for these adverse effects if you have diabetes, and take diabetes medication orally. These could be signs of hypoglycemia and could lead to unconsciousness.
The U. S. Food and Drug Administration (FDA) has found that, while rare, fluoroquinolone antibiotics like Cipro can increase the occurrence of severe ruptures or tears in your aorta (a large artery that begins in the heart). These ruptures can lead to dangerous aortic bleeding, a heart attack, or even death, so people at risk for cardiac problems should be cautious about taking Cipro.
Be sure to tell your doctor if you have been diagnosed with or have a history of other medical conditions, including a prolonged QT interval (a rare heart problem that may cause an irregular heartbeat, fainting, or sudden death), aneurysms, kidney disease, liver disease, heart disease, myasthenia gravis (severe muscle weakness), seizures, or diabetes. Cipro can also significantly increase theophylline levels in your blood, leading to serious illness or death. This is not a comprehensive list of medical conditions that Cipro may affect, so speak with your doctor about your medical history before taking Cipro.
Cipro can cause your skin to become sensitive to sunlight or ultraviolet light, so try to avoid unnecessary sun exposure and do your best to wear protective clothing, sunglasses, or sunscreen that is SPF 15 or higher. Call your doctor if you notice redness, swelling, or blistering from sun exposure while on Cipro.
As with all prescription medication, inform the prescribing doctor about any medical conditions you have been diagnosed with and any medications or supplements you currently take before starting treatment. Antacids can reduce the amount of Cipro that your body absorbs, so be sure to take them at least 2 hours before or 6 hours after taking antacid medications.
In addition, let your doctor know if you are breastfeeding, pregnant, or planning on becoming pregnant before starting treatment with this medication.
If a doctor wants to increase the dose of Cipro to 5 milligrams per day, do not use on more than 5 milligrams.
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